Filtering data with probabilistic filters for content selection
US patent 11657407
01 / Background
Experience
& education
Professional experience
2022 — present
Software Development Engineer
WhatsApp / Meta
Facebook London.
- WhatsApp Integrity: spam, scam and scraping prevention
- Harm measurement infrastructure within an end-to-end encrypted environment
- Reducing impact on legitimate users
2014 — 2022
Senior Applied Scientist
Amazon Development Centre Scotland
- Sponsored Display and Dynamic Ads: personalised and contextual advertising with machine learning
- Architecture and design of distributed systems for large datasets, high transaction volumes and very low latencies
- Measurement and optimisation of advertising systems supporting significant revenue
2009 — 2014
Computational Biologist
University of Glasgow
Research base: CRUK Beatson Institute for Cancer Research
- Computational research into cellular senescence and cancer
- Whole-genome sequencing, gene expression, epigenetic and structural analyses
Education
2006 — 2011
PhD, Computing Science
University of Glasgow
2001 — 2006
MSci, Computing Science
University of Glasgow
02 / Invention
Patents
Content selection, data processing and privacy.
US 11657407 Retargeting events service for online advertising
US patent 10559001 and 10936258 and 11256453
Preventing duplicate content selection for digital presentation
US patent 10825064
Privacy-based content tracker
US patent 10943269
Caching selected data for use in real-time content selection
US patent 11087365
Parallel data pool processing and intelligent item selection
US patent 11113730
03 / Research
Publications
Research in computational biology, epigenetics and human–computer interaction.
2020
MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer.
British Journal of Cancer 122 (6), 868-884, 2020.
Read PDF DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation.
iScience 23 (2), 100838, 2020.
2018
MYC expression promotes lipid metabolism and metabolic plasticity in human mammary epithelial cells.
Cancer Research 78 (13 Supplement), 1441-1441, 2018.
2017
Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions.
Genome biology 18 (1), 1-16, 2017.
Oncogene-expressing senescent melanocytes up-regulate MHC class II, a candidate melanoma suppressor function.
Journal of Investigative Dermatology 137 (10), 2197-2207, 2017.
2016
Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability.
Genome Biology, 17:158, 2016.
2014
HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia.
Genes & Development, 2014.
DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML.
Genome Biology, 2014.
A comparison of oncogene-induced senescence and replicative senescence : implications for tumor suppression and aging.
Age, 2014.
Investigating effects of epigenetic modulation in acute myeloid leukaemia.
Lancet, 383(Supl 1), S70. 2014.
The effects of aging on the expression of Wnt pathway genes in mouse tissues.
Age, 2014.
Phase II trial of Vorinostat in advanced melanoma.
Investigational New Drugs, 2014.
Epigenetics.
Pharmacogenomics and Stratified Medicines, S. Padmanabhan (Ed.), Elsevier, 2014.
2013
Senescent cells harbor features of the cancer epigenome.
Nature Cell Biology, 2013.
* Joint first authors.
Wnt signaling potentiates nevogenesis.
Proc. Natl. Acad. Sci., 110(40):16009-14, 2013.
Lamin B1 Depletion in Senescent Cells Triggers Large Scale Changes in Gene Expression and in the Chromatin Landscape.
Genes and Development, 27(16):1787-99, 2013.
Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment.
Stem Cell Research & Therapy, 4(2):36, 2013.
Placing the HIRA Histone Chaperone Complex in the Chromatin Landscape.
Cell Reports, 3(4):1012-9, 2013.
2012
Dynamic Configuration of Home Services.
Advances in Home Care Technologies: Results of the MATCH Project, K.J. Turner (Ed.) IOS Press. 2012.
Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts.
Mechanisms of Ageing and Development, 133(7):498-507, 2012.
2011
Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.
Molecular and Cellular Biology, 31(19):4107-18, 2011.
Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis.
Molecular Cell, 42(1):36-49, 2011.
A Generic Approach to the Evolution of Interaction in Ubiquitous Systems.
Ph.D. Thesis, University of Glasgow, 2011.
2010
Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci.
Cell Division, 5:16, 2010.
How Viable are Stubblefield and Simon's Inkblots as Password Cues?
In Privacy and Usability Methods Pow-wow (PUMP). University of Abertay, Dundee. 2010
2009
User Configuration of Activity Awareness.
In Distributed Computing, Artificial Intelligence, Bioinformatics, Soft Computing, and Ambient Assisted Living, Salamanca, Spain, 2009.
2008
An Integrated Approach to Supporting Interaction Evolution in Home Care Systems.
In 1st International Conference on Pervasive Technologies Related to Assistive Environments, Athens, Greece, 2008.
A Model-Based Approach to Supporting Configuration in Ubiquitous Systems.
In Design, Specification and Verification of Interactive Systems 2008, Kingston, Ontario, Canada, 2008.
Password cueing with cue(ink)blots.
In IADIS Computer Graphics and Visualization 2008, Amsterdam, The Netherlands, 2008.
2007
Audio Reminders in the Home Environment.
In International Community on Auditory Displays, Montreal, Canada, 2007.
A Scalable Home Care System Infrastructure Supporting Domiciliary Care.
Technical Report CSM-173, University of Stirling, 2007.
A Generic Approach to the Evolution of Interaction in Ubiquitous and Context-Aware Systems.
Technical Report TR-2007-260, University of Glasgow, 2007.
2006
Textual Associations from Images Applied to Authentication
Masters (M.Sci.) Thesis, University of Glasgow, 2006.